NexGard® contains afoxolaner, a novel member of the isoxazoline chemical class. Afoxolaner kills fleas and ticks by targeting a distinct binding site within nerve cell membrane GABA (gamma aminobutyric-acid), the modulated chloride channels, resulting in uncontrolled hyperexcitation and death.

NexGard® is a once a month oral palatable braised beef flavouring soft chew with a recommended minimum dose level of 2.5mg/kg body weight is effective against fleas and ticks with published efficacy studies on generalised demodecosis, sarcoptic and otodectic mange. Each chew contains 2.27% w/w of afoxolaner.

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